Acute Respiratory Distress Syndrome and Stem Cells

B, Jones D, Joyce C, Kostner K, et al.; The ANZ-STATInS Investigators– ANZICS Clinical Trials Group. A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med 2013;187:743–750. 3. Craig T, O’Kane CM, McAuley DF. Potential mechanisms by which statins modulate pathogenic mechanisms important in the development of acute lung injury. In: Vincent JL, editor. 27th Yearbook of Intensive Care and Emergency Medicine. Berlin: Springer-Verlag; 2007. 4. Al Harbi SA, Tamin HN, Arabi YM. Association between statin therapy and outcomes in critically ill patients: a nested cohort study. BMC Clin Pharmacol 2011;11:12. 5. Jacobson JR, Barnard JW, Grigoryev DN, Ma S-F, Tuder RM, Garcia JGN. Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. Am J Physiol 2005;288:L1026–L1032. 6. Shyamsundar M, McKeown S, O’Kane C, Craig T, Brown V, Thickett DR, Matthay MA, Taggart C, Backmann J, Elborn JS, et al. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med 2009;179:1107–1114. 7. Patel JM, Snaith C, Thickett DR, Linhartova L, Melody T, Hawkey P, Barnett AH, Jones A, Hong T, Cooke MW, et al. Randomized doubleblind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS trial). Crit Care 2012;16:R231. 8. Craig TR, Duffy MJ, Shyamsundar M, McDowell C, O’Kane CM, Elborn JS, McAuley DF. A randomized clinical trial of hydroxymethylglutarylcoenzyme A reductase inhibition for acute lung injury (the HARP study). Am J Respir Crit Care Med 2011;183:620–626. 9. McAuley DF, Laffey JG, O’Kane CM, Cross M, Perkins GD, Murphy L, McNally C, Crealey G, Stevenson M. Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial. Trials 2012;13:170. 10. Chopra V, Rogers MA, Buist M, Govindan S, Lindenauer PK, Saint S, Flanders SA. Is statin use associated with reduced mortality after pneumonia? A systematic review and meta-analysis.Am JMed 2012;125:1111–1123. 11. Steiner S, Speidl WS, Pleiner J, Seidinger D, Zorn G, Kaun C, Wojta J, Huber K, Minar E, Wolzt M, et al. Simvastatin blunts endotoxininduced tissue factor in vivo. Circulation 2005;111:1841–1846. 12. Kruger PFK, Cook D, Jones M, Nimmo G. Statin therapy is associated with fewer deaths in patients with bacteraemia. Intensive Care Med 2006;32:75–79.